Moreover, Mettl5 KO promotes leukemia growth by translationally inhibiting F-box and WD repeat domain-containing 7 (Fbxw7) (Xing et al. 2020; Yeh et al. 2018; King et al. 2013), a c-MYC degrader and a key regulator of cell differentiation. Here, FBXW7 is linked to leukemia.