CD8A and neoplasm: Within the tumor (Fig. 3E), a cell was termed ‘PB-related T cells’ if its club contained PB T cells; otherwise, it was classified as ‘PB-unrelated T cells.’ We found a significant number of activated cells, such as effector and memory CD8 cells, were associated with PB, whereas many exhausted CD8 T cells in the tumor were unrelated to PB T cells (Fig. 3F; Appendix Fig. S12).