EGFR and neoplasm: To determine whether ERO1A expression was causative for phenotypes predicted to contribute to tumor progression, as well as secretion of matrix, two ERO1A knockout EGFR-mutated isogenic cell line models, referred to as HCC4006 and HCC4006 ERO1A KO and PC-9 and PC-9 ERO1A KO, were established (Fig. 4A).