Based on the gene expression changes observed in colonic ILCs in our pre-clinical model of CPI-induced colitis, upstream analysis predicted significant activation of proximal mediators, such as cytokines that induce IFNγ production (Il18, Il21, Il27 and Il2), transcription factors (Tbx21), and MAPK kinases (Map2k1/2), flagging them as potentially druggable targets. Here, IL18 is linked to isolated cleft palate.