APOL1 and hypertensive disorder: In a novel and unexpected finding, transgenic pregnant G2-genotype mice developed a preeclampsia/eclampsia phenotype with pregnancy-induced hypertension, proteinuria, seizures, fetal/neonatal deaths, and small litter sizes.[28] Moreover, this study arose a new perspective towards the connection between APOL1 and PE: the occurrence of the preeclampsia/eclampsia phenotype was also related to the APOL1 genotype of the pup.