Apart from that, HADS (Hospital Anxiety and Depression Scale) was adopted to evaluate the magnitude of anxiety symptoms and depression due to insomnia, while free radicals, Serum MDA (Malondialdehyde), XOD (Xanthineoxidase), SOD (Superoxide dismutase), and CAT (Catalase), for postmenopausal women aging. The gene discussed is CAT; the disease is major depressive disorder.