Studies confirmed that not only regulated the body, but more importantly, regulated the mental state, which can exercise the coordination and flexibility of the nervous system, relieve brain fatigue, and regulate emotions.[69] Some studies also showed that Baduanjin effectively increased the levels of adiponectin levels[70] and monoamine[71] and regulated the dysregulated expression of lncRNA, mRNA, and circRNA,[72] which potentially contributed to reducing depression and anxiety in menopausal women, the sleep disorders were relieved. Here, ADIPOQ is linked to major depressive disorder.