These elements play a crucial role in the initiation and progression of cancer.[47] In contrast to platelets and neutrophils, lymphocytes operate as anti-tumor agents by triggering the p53 signaling pathway and secreting IL-17 to cause tumor cell death and stop tumor cell growth.[48] Besides, persistent activation of T cells can enhance the anti-tumor effects of tumor-infiltrating T lymphocytes, leading to the apoptosis of cancer cells by presenting tumor-associated antigens to lymphocytes. The gene discussed is TP53; the disease is neoplasm.