Nuclear factor-kappa B (NF-KB) plays a significant role in leukemogenesis and is a critical regulator of cancer development and inflammation.[25] According to a study, HHT exhibits dual effects in t(8;21) leukemia, suppressing leukemia-initiating cells and downregulating MYC pathway-associated gene expression.[26] The second double-strand RNA-binding motif (DSRM2) was used to identify the nuclear localization signal for the NF-KB repression factor (NKRF). This evidence concerns the gene NKRF and leukemia.