TNFRSF10A and cancer: According to reports, the cancer treatment drug tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has a significant apoptotic effect in cancer cells but not in normal cells.[91] By engaging with its corresponding receptors in cells, death receptor 4 and death receptor 5, TRAIL initiates the death receptor-mediated apoptotic signaling (extrinsic) cascade.