PTEN and acute myeloid leukemia: An oncogene in AML has been identified as long noncoding RNA MIR17HG.[37] A further study found that the well-known tumor-suppressive miRNA miR-21 could target PTEN and cause HHT resistance.[38,39]MIR17HG may control the miR-21/PTEN axis to modify AML cell chemoresistance.