The oncoprotein eukaryotic translation initiation factor 4E (eIF4E), which binds to the cap of messenger RNA (mRNA), is crucial for the initiation and progression of cancer.[49] However, phosphorylation of eIF4E is necessary for tumor formation, and AML cells in particular need phospho-eIF4E (p-eIF4E).[50,51] In particular, a study revealed that p-eIF4E could be effectively inhibited by using small molecule inhibitors of MNK, which phosphorylates eIF4E.[52]. This evidence concerns the gene EIF4E and neoplasm.