HIF1A and hepatocellular carcinoma: Recently, it has been found that inhibition of the HIF-1α/GLUT1 pathway can effectively increase the sensitivity of hepatocellular carcinoma to 5-caffeoylquinic acid.[40] This finding provides a new idea to solve the drug resistance problem faced in chemotherapeutic drug treatment, such as the combination of chemotherapeutic drugs and anti-resistant drugs or alternating application and other programs, and this idea also needs to be confirmed by corresponding studies.