HIF1A and neoplasm: At the same time, HIF-1α upregulation also contributes to the maintenance of stem cell-like properties of tumor cells, including the ability of self-renewal and differentiation.[15] In the process of glycolysis, there are multiple biological enzymes, which have crucial regulatory roles in glycolysis, and in the process of aerobic glycolysis in tumor cells, there are multiple pathways to regulate the expression of these biological enzymes to maintain the energy required for the life activities of tumor cells.