A variety of substances have been found to regulate the metabolic reprogramming of tumor cells, among which, hypoxia-inducible factor-1α plays a central role in tumor cell metabolic reprogramming.[2] Understanding hypoxia inducible factor-1α (HIF-1α) is of great significance for understanding tumor pathogenesis, exploring novel antitumor drugs and preventing antitumor drug resistance. Here, HIF1A is linked to neoplasm.