6-Phosphofructokinase-2/fructose-2,6-bisphosphatase 3 (6-phosphofructokinase-2/fructose-2,6-bisphosphatase 3, PFKFB3) can phosphorylate fructose 6-phosphate to fructose-2,6-bisphosphate, which in turn activates PFK1 and increases glycolytic flux in cancer cells. Here, PFKFB3 is linked to cancer.