According to previous studies, inflammation can promote changes in the body’s IGF-1 level, inducing lymphocyte differentiation and immunoglobulin production by increasing its level and inhibiting inflammation.[6] However, the specific mechanisms of CRP, IL-6, and IGF-1 in postoperative secondary infections in LC patients need to be further clarified. This evidence concerns the gene CRP and laryngotracheoesophageal cleft.