TSPO and Anxiety: In a mouse model of sepsis induced by the administration of lipopolysaccharide (LPS), TSPO expression increased in hippocampal microglia, and the administration of a TSPO antagonist ameliorated the associated behavioral abnormalities.[7] In addition, in another study of a mouse model of sepsis induced by cecal ligation and puncture, mice with TSPO deletion exhibited prolonged weight loss compared with wild-type mice, and during the recovery phase, significant depressive- and anxiety-like behaviors, as well as muscle weakness, were observed.[8]