Several studies have explored the molecular mechanisms behind the formation and function of this fusion protein,[8,14–16] providing evidence that the ASPSCR1–TFE3 fusion protein plays a crucial role in the development and progression of ASPS by promoting angiogenesis, regulating cell cycle progression, and modulating the transcription of genes involved in lipid metabolism. Here, TFE3 is linked to alveolar soft part sarcoma.