Highly associated pathways such as KEGG "Type I Diabetes," "Antigen processing and presentation," and "Systemic lupus erythematosus" share several genes, particularly HLA class I and II paralogs (HLA-DRB1, HLA-DQB1, HLA-DQA1, HLA-B). This evidence concerns the gene HLA-DRB1 and systemic lupus erythematosus.