Studies on the mechanism of YAP1 involved in vascular diseases mainly focus on the endothelial cell (EC) and the vascular smooth muscle cell (VSMC), YAP1 contributed to EC dysfunction in the process of atherosclerosis, EC proliferation in hypertension and angiogenesis; YAP1 also induced VSMC proliferation, migration and phenotype transformation in vascular diseases.25 The gene discussed is YAP1; the disease is atherosclerosis.