YAP1 plays an important role in vascular remodelling,7 YAP1 can regulate the function of AF through various ways; changes in mechanical stress and hemodynamics can activate YAP1, and subsequently YAP1 regulates the phenotypic transformation and migration of AF, thereby causing vascular matrix remodelling.8, 9, 10. This evidence concerns the gene YAP1 and atrial fibrillation.