This is because, with aging, the immune system’s functional decline is characterized by a shift from a naïve T-cell phenotype to a memory T-cell phenotype, a transition from a Type 1 to a Type 2 cytokine profile, humoral immune deficiencies, increased T-cell maturation rates, chronic low-grade inflammation, and many other changes [36, 37]. The gene discussed is SGCG; the disease is immunodeficiency disease.