Patients with pathogenic TUBA1A variants and various eye anomalies such as coloboma (PMID: 26130693, PMID: 38502138), microphthalmia and cataracts (PMID: 26294046) have been reported, demonstrating the importance of this gene in eye development, structure and function [26–28]. Here, TUBA1A is linked to microphthalmia.