We propose that this disparity may arise from the prolonged progression of CAC, where PXR plays diverse roles in the transition from inflammatory bowel disease to cancer, significantly influencing colon cancer progression, metastasis, migration and chemotherapy resistance, while being closely linked to tissue specificity, inflammatory environment and individual variabilities.39, 40, 41, 42. The gene discussed is NR1I2; the disease is colonic neoplasm.