Analysis of tumour tissues from the PXR‐expressing mouse models exhibited a significant decrease in P‐STAT3 expression, reduced levels of IL‐6 and IL‐1β proteins in GV358‐LV cells xenotransplanted nude mice models, along with an increase in Bax expression and decreases in Bcl‐2, Cyclin D1 and CDK‐4 proteins. The gene discussed is CDK4; the disease is neoplasm.