In detail, in serous ovarian cancer cells ET-1, acting through the endothelin A receptor (ETAR), a member of the G protein couple receptor family, mediates the recruitment of multiple invadopodia-activating signaling pathways, including the Rho GTPases-mediates signals, coordinating invadopodia dynamics [11–15]. The gene discussed is EDN1; the disease is ovarian serous adenocarcinoma.