FGF21 and Cowden disease: Furthermore, they found differences in FGF-21, IFN-gamma, TNFRSF9, CXCL10, CXCL9, and OPG between CD and UC.24 Our study also detected significant differences in FGF-19, MMP-10, IL-10, and CXCL9 when comparing ileal CD and UC, as well as between ileal CD and colonic CD.