However, in hemodynamically unstable children with cancer during sepsis and evidence of oxygen deficiency (e.g., use of inotropes, elevated lactate), it is suggested to consider an Hb threshold ranging between 4.3 mmol/L and 6.2 mmol/L as part of a comprehensive approach to improve oxygen delivery for children with unstable non hemorrhagic shock and evidence of oxygen debt (WEAK recommendation) [24]. The gene discussed is GSTM1; the disease is Sepsis.