The analysis of loss-of-function variants identified a total of 116 endometrial cancer risk loci (p < 0.01), including seven loci (SLC6A3, ANTXRL, TERT, SLCO1B3, SALL3, LPCAT1 and MSH2) that met genome-wide significance (Fig. 1; Supplementary Table S7). Here, SLC6A3 is linked to endometrial cancer.