On the cellular level, angiotensin II (Ang-II)/Ang-II receptor type 1 (AT1R) or IL-17/IL-17RA signaling reduces endothelial NO bioavailability, impairing endothelial-mediated vasodilation in salt-sensitive and Ang-II-induced hypertension (31, 42, 80). The gene discussed is IL17RA; the disease is Hypertension.