In detail, in a rodent model at stages comparable to midlife hypertension, that is, early disease, microglia were activated and—compared with age-matched normotensive controls—the expression of different surface proteins (e.g., CD11b/c, CD86, P2Y12R, CD200R, major histocompatibility complex II) were increased. This evidence concerns the gene CD200R1 and hypertensive disorder.