For instance, the mAb 2G12 neutralizes human immunodeficiency virus-1 (HIV-1) by recognizing oligomannose-type N-glycans on the HIV-1 gp120 envelope protein, and the mAb FH6 specifically binds the Sialyl Lewis X (SLeX) antigen on the surface of various cancer cells (Trkola et al., 1996; Fukushi et al., 1984; Kannagi et al., 1986). Here, ITIH4 is linked to cancer.