In addition, the mRNA levels of both neutrophil gelatinase-associated lipocalin (Ngal) and kidney injury molecule 1 (Kim-1), which are markers of acute kidney injury, were significantly increased in the kidney tissues from WT and S4KO mice following injury (Figure 2D and H and Figure 2—figure supplement 1D). The gene discussed is HAVCR1; the disease is acute kidney injury.