RAC1 and cancer: Key integrin-mediated signaling proteins that were implicated in cancer cell plasticity, adhesion, migration, and survival (reviewed in Cooper and Giancotti, 2019) also had significantly decreased TE, specifically, proto-oncogenes Crk (CRK) and Crk-L (CRKL), PRKCA – a catalytic subunit of PI3-kinase, Rac1 GTPase (RAC1), JNK2 (MAPK9), as well as Abl1 kinase (ABL1) and BCR activator of Rho-GEF (BCR).