AKT1 and Familial prostate cancer: Given the low number of DTEGs, we observed no significant enrichment of any KEGG pathway within the upregulated DTEGs and only a few significant enrichments for the eIF3hKD ‘all downregulated’ DTEGs in pathways like ‘Prostate cancer’, ‘Viral carcinogenesis’ or ‘PI3-Akt signaling pathway’, all of which included only two common hits – MDM2 and ATF4 (Figure 6A, Supplementary file 2A).