GSX2 and neoplasm: NB-FOXR2 tumors are not the only tumor type to be associated to a cortical interneuron lineage; H3.3G34R/V HGGs originate in GSX2+ interneuron progenitors, and the chromatin state at the GSX2 locus in this cell context underlies the vulnerability to PDGFRA alterations (10, 69, 70).