These ex vivo cell lines recapitulated expression patterns present in human NB-FOXR2 tumors, displaying high levels of the GE-specific TFs Lhx6, Nkx2-1, Dlx5, and Dlx6, which suggest that they arose from a medial GE progenitor lineage (Fig. 7B). The gene discussed is LHX6; the disease is neuroblastoma.