Although FOXR2 is a pan-cancer oncogene (7), the unifying molecular and IHC profiles of NB-FOXR2 tumors suggest a shared lineage of origin, as is the case for other brain tumor types, including hemispheric histone 3 G34R/V gliomas (10), midline histone 3 K27M gliomas (11), and subtypes of medulloblastomas (12–14). Here, FOXR2 is linked to central nervous system cancer.