We show that targeting Foxr2 and p53 loss of function (p53LOF) to the ventral telencephalon in mice by in utero electroporation (IUE) is sufficient to induce brain tumors recapitulating human NB-FOXR2, with transcriptional features of ganglionic eminences (GE)–derived lineages. The gene discussed is FOXR2; the disease is brain neoplasm.