Intervention patients compared to usual care patients:Increased self-management behavior (58.73–83.98 vs. 58.85–73.14), decrease in anxiety (57.07–39.32 vs. 56.87–46.95) and depression (44.59–31.90 vs. 45.23–40.77) score, and higher nutritional indices (increased upper arm circumference, upper arm muscle circumference, triceps skin fold thickness, body mass index, albumin, prealbumin, and hemoglobin). The gene discussed is TTR; the disease is depressive symptom measurement.