The most notable include the Barcelona Clinic Liver Cancer (BCLC) classification,13,14 Hong Kong Liver Cancer (HKLC),15 and Italian Liver Cancer (ITA.LI.CA) staging systems,17 each of which include variables related to tumor stage and liver function; in contrast, the albumin-bilirubin (ALBI) grade only is based on liver function among patients with HCC.18 The gene discussed is ALB; the disease is hepatocellular carcinoma.