However, the microsatellite instable (MSI)/MSS status was available for only 146 of the 302 patients, and only 8 patients were MSI high.11 In the current study, α-SMA expression was evaluated holistically in the tumor stroma across all compartments and revealed wider associations with T stage, grade, vascular and perineural invasion, infiltrative tumor edge pattern, and proficient MMR status, revealing the importance of α-SMA assessment in CRC. This evidence concerns the gene ACTA1 and colorectal carcinoma.