ACTA1 and neoplasm: Investigation of α-SMA stromal expression in individual tumor compartments revealed that higher peripheral α-SMA stroma H-scores were associated with T4 stage (P = .002), perineural invasion (P = .038), involved nodal status (P = .036), disease recurrence (P = .004), metastasis (P = .013), synchronous metastasis (P = .007), and poorer 3-year (P = .018) and 5-year survival status (P = .018) TABLE 2.