ACTA1 and neoplasm: Higher α-SMA stromal H-scores in pMMR tumors were associated with similar poor prognostic variables, including higher T stage (P = .00005), vascular invasion (P = .02), perineural invasion (P = .021), infiltrative tumor edge pattern (P = 6.3029 × 10–8), and disease recurrence (P = .002) TABLE 1.