Although mitophagy plays a double‐edged sword role in multiple cardiovascular diseases, our previous study demonstrated that mitophagy, especially mediation by NDP52, aggravates cardiac dysfunction, and damages cardiac structure, which accelerates RIHD.[11, 38] Therefore, targeting initiation and activation of mitophagy to explore the RIHD pathogenesis and study potential therapeutic drugs has become an important direction in the field of radiation injury. This evidence concerns the gene CALCOCO2 and cardiovascular disorder.