P4HB and cardiovascular disorder: Lactylation as a novel posttranslational medication plays a critical regulatory role in cardiovascular diseases.[16, 46] As first reported by Zhao, lactylation provides a prospective perspective on the pathological mechanisms and drug targets of numerous diseases.[15] Lactylation omics showed that P4HB was a potential lactylated protein involved in X‐ray‐induced RIHD.