HNRNPA1 and cancer: In the case of the topoisomerase-inhibitor irinotecan, two genes seem to be highly predictive: HNRNPA1, an abundant and ubiquitously expressed member of the hnRNP family of heterogeneous-nuclear-ribonucleoproteins, and CMTM7, or CKLF-like MARVEL transmembrane domain-containing protein 7, a gene involved in various cellular processes, including immune regulation and cancer development.