Glucose 6‐phosphate dehydrogenase (G6PD) mutant melanomas have shown reduced circulating melanoma cells and metastatic burden, exhibiting increased oxidative stress, decreased NADPH, and reliance on malic enzyme activity and glutaminase for compensating oxidative stress, highlighting the layered protective mechanisms conferred by the pentose phosphate pathway, malic enzyme, and glutaminolysis [12]. The gene discussed is GLS; the disease is melanoma.