Fourth, given the high median age of patients with IgAN in this study, we could not completely exclude the confounding effect of hypertensive nephrosclerosis with IgA deposition, although there were no significant differences in the prevalence of hypertension, interlobular artery intimal thickness, and arteriolar hyalinosis between the low-PSI and high-PSI groups. The gene discussed is CD79A; the disease is hypertensive disorder.