Further, in a study that aimed to quantify two adipokine molecules (ghrelin and chemerin) released in association with food intake and obesity in periodontally healthy and diseased individuals across different body mass categories, it was shown that both groups with chronic periodontitis had statistically significantly higher levels of chemerin in serum than the group of periodontally healthy/gingivitis individuals with BMI <25 kg/m2.71 Here, RARRES2 is linked to obesity due to melanocortin 4 receptor deficiency.