In an observational study comparing ICAM‐1, E‐Selectin and myeloperoxidase levels in individuals with moderate‐to‐severe chronic periodontitis and individuals with gingivitis or incipient periodontitis, data analysis showed significantly higher plasma levels of E‐selectin, myeloperoxidase (MPO), and ICAM‐1 in patients with moderate‐to‐severe periodontitis after adjusting for age and waist circumference.96 This evidence concerns the gene ICAM1 and gingivitis.