reported that cf‐DNA can promote macrophage pyroptosis via overactivated NLRP3 inflammasome in Sjögren's syndrome.[15] Several studies have demonstrated that pyroptosis may play a major role in the development of non‐alcoholic steatohepatitis (NASH).[16] In addition, inflammasome‐mediated pyroptosis is critical for the inflammatory response and severity of liver injury.[17] In ConA treated mice, the levels of NLRP3, Cleaved caspase‐1, and IL‐1β in the livers were significantly elevated, and there was a pyroptosis. Here, IL1B is linked to metabolic dysfunction-associated steatohepatitis.