In contrast, NLRP3−/− and caspase‐1−/− mice demonstrate suppressed development of autoimmune hepatitis, with a reduction in liver injury, ALT levels, and pyroptosis.[18] NLRP3 activation correlates with disease activity in patients with PBC.[19] Our data showing that autoreactive CD8+ T cells induce hepatocyte pyroptosis has implications that extend beyond the murine model used in this study. The gene discussed is CD8A; the disease is primary biliary cholangitis.