Disulfiram (DSF) is a FDA‐approved drug that has been used for decades to treat chronic alcohol addiction.[36] Due to its confirmed safety, disulfiram is being repurposed, most notably for its role in regulating pathways and stress response through direct targeting of NPL4.[37] In a recent study, disulfiram has been reported to be a specific inhibitor of GSDMD‐mediated pore formation, without affecting other GSDMs‐mediated pyroptosis pathways.[9]. Here, NPLOC4 is linked to Addictive alcohol use.