To further explore the role of PD‐1+CD8+ T cells in the development of autoimmune liver diseases in dnTGFβRII Aire−/− mice, we designed CAR‐T cells, which specifically targeting PD‐1+ cells and conducted in vivo experiments to deplete PD‐1+ cells in the model mice (Figure 5A). This evidence concerns the gene PDCD1 and autoimmune hepatitis.