While inflammatory markers broadly correlated with altered spike IgG Fc glycan abundances, our correlation analyses identified only a few significant relationships between cytokine levels and spike glycan abundances in adult acute COVID-19 groups: a negative correlation between galactosylation and IL-6 (OS5/7), and positive correlations between bisection and IL-6 (OS4) and IFN-γ (OS5/7). This evidence concerns the gene IFNG and COVID-19.