While PD-L1 expression is generally low in skin keratinocytes, CD8+ T cell infiltration and PD-L1 expression have also been reported in glandular and basal skin biopsies from focal lesions in patients experiencing TEN associated with tumor immunotherapy (Li et al., 2023a; Vivar et al., 2017). This evidence concerns the gene CD274 and toxic epidermal necrolysis.