APOA2 and colon adenocarcinoma: APOA2 is known to be involved in high density lipoprotein (HDL) metabolism (Wang et al., 1997), while acyl-CoA thioesterase 7 (ACOT7) is important in unsaturated fatty acid biosynthesis which is involved in the initiation and progression of colon adenocarcinoma (COAD) (Chen et al., 2022).