FH and neoplasm: As mass spectrometry results accompanied by the bioinformatics enrichment of identified proteins in analyzed tumor tissues revealed several deregulated molecular processes associated with disease progression (including lipid metabolism, tricarboxylic acid cycle, unfolded protein response [UPR] and the process of translation), in this study the relative expression levels of apolipoprotein A2 (APOA2), 40S ribosomal protein S3 (RPS3), acyl-CoA thioesterase 7 (ACOT7), fumarate hydratase (FH) and DnaJ homolog subfamily C member 3 (DNAJC3) were additionally validated by Western blot (Figure 4).