Besides, accumulating evidences have demonstrated that paeonol and forsythoside A, the effective components in JJJG, can act on the key pathological mechanism of (IL-6, TNF-α, IL-1β)/JAK2/STAT3/VEGF in the treatment of liver cancer and acute lung injury (Yu and Liang, 2017; Lu et al., 2020). This evidence concerns the gene IL1B and liver cancer.