The whole results confirmed that JJJG can reduce swelling and improve nodule lesions, thus effectively treating thyroid nodules by regulating FT3, FT4 and TSH levels in serum, simultaneously reducing inflammatory factors in thyroid tissue, inhibiting the activation of JAK2/STAT3 signaling pathway, and reducing VEGF expression (Figure 13). The gene discussed is VEGFA; the disease is thyroid nodule.