Intersection of DEG of pericentral hepatocyte of mice with mid-stage, late-stage and HFD/STZ gene profiles revealed 25 genes (Figure 4D), including fatty acid and carbohydrate metabolism, transporter, xenobiotic metabolism, and two soluble factors (S100a10 and Selenop) were upregulated in the pericentral hepatocytes of mice with T2DM (Figure 4E). The gene discussed is SELENOP; the disease is type 2 diabetes mellitus.