As shown in Figure 7J, the interactions between periportal and pericentral hepatocytes, mediated by Fgf, Agt, Nectin1, Vtn, Sema4a, Angpt, Fn1, and Des, were lost in the livers of mice with diabetes at the late-stage (Figure 7J,K). The gene discussed is SEMA4A; the disease is diabetes mellitus.