Lung-friendly cancer cells secrete sEVs enriched in integrin α6β4, and sEVs derived from lung-ophilic BC cells preferentially fuse with lung fibroblasts and lung epithelial cells; integrin α6β4 may interact with extracellular matrix components to mediate sEVs uptake at specific target sites within the lung, which in turn activates Src phosphorylation 27-29. This evidence concerns the gene SRC and breast cancer.