TLR4 is also involved in various signaling pathways, such as Nuclear factor-kappaB (NF-κB), NOD-like receptor thermal protein domain associated protein 3 (NLRP3), etc. NF-κB is one of the significant factors linking cancer and inflammation, and it induces cytokines of the immune response, including TNFα, IL-1, IL-6, and IL-8, as well as adhesion molecules therein, which allow inflammatory sites to leukocytes can be recruited. The gene discussed is NFKB1; the disease is cancer.