Consistent with this finding, Lee et al. showed the inhibitory role of CAP on the expression of psoriasis-related cytokines and chemokines IL6, IL17, IL22, CCL20, CXCL1, and suppression on Th17 cell differentiation using a psoriasis mice model; also in this study, CAP was found capable of enhancing PD-L1 expression in HaCaT cells, suggestive of the role of CAP in counteracting T cell over-activation 76. Here, CD274 is linked to psoriasis.