Furthermore, OAS3 overexpression-induced apoptotic cell number significantly decreased after inhibition of RNase L with EA and Myr in MLE12 cells under LPS stimulation in vitro (Fig. 7B) or in mice under CLP operation in vivo (Fig. 7C-D), suggesting that OAS3 aggravates cell apoptosis via RNase L in sepsis. The gene discussed is OAS3; the disease is Sepsis.