Further, the Co-IP result showed that the interaction between OAS3 and TRIM21 was significantly reduced in MLE12 cells in response to LPS treatment (Fig. 5C) or in lung tissue of CLP mice (Fig. 5D), suggesting that the impaired interaction between OAS3 and TRIM21 may result from the downregulation of TRIM21 expression in response to sepsis. The gene discussed is TRIM21; the disease is Sepsis.