IL1B and inflammatory bowel disease: Restivo et al.307 assessed the anti-inflammatory effects of a polyethoxylated flavone fraction (PMFF) from Citrus sinensis (particularly rich in nobiletin) and a prenylflavonoid fraction (PFF) from Humulus lupulus (with high levels of XN) both individually and combined (MIX), using an IL-1β-stimulated Caco-2 cell model of IBD.