BAX and ulcerative colitis: Hesperetin was also shown to alleviate TNBS-induced ulcerative colitis through antioxidant (increasing GSH and SOD while decreasing NO content), anti-inflammatory properties (reducing IL-6, TNF-α, CD45 and NF-kB), antiapoptotic (diminishing caspase 3 and Bax expression) and through modulating JAk2/STAT3/SOCS3 170,171.