PLCG2 and neoplasm: The mIHC results of subcutaneous tumor tissues indicated a significantly lower expression of phosphorylated Akt proteins (Ser473 and Thr308) and phosphorylated mTOR proteins (Ser2481 and Ser2448) in oe-PLCG2+MK2206 group in contrast to oe-PLCG2 group (Figure 8G).