In this study, we found a positive correlation that the expression of PLCG2 was significantly increased with the upregulation of immune checkpoints such as CD274, PDCD1, LAG3 and CTLA4 via bioinformatics analysis and observed that PLCG2 could promote the formation of tumor immunosuppressive microenvironment by inducing the infiltration of immune-suppressing cells (M2 macrophages and Treg cells) and inhibiting the infiltration of immune-activating cells (NK cells and CD8+ T cells). Here, PLCG2 is linked to neoplasm.