Subcutaneous xenograft tumors in nude mice showed significantly greater tumor volume and weight in PLCG2 overexpression group (oe-PLCG2) than in the control group (oenc-PLCG2), but tumor volume and weight in oe-PLCG2 group that had undergone MK2206 administration (oe-PLCG2+MK2206) were significantly suppressed and lower than that in oe-PLCG2 group (Figure 8F). This evidence concerns the gene PLCG2 and neoplasm.