Overexpression of PLCG2 significantly decreased the ratios of Cleaved Caspase-3/Caspase 3 and Bax/Bcl-2, whereas knockdown of PLCG2 significantly increased the ratios, indicating that overexpression of PLCG2 increased the expression of the apoptosis-inhibiting related proteins and decreased the expression of apoptosis-promoting related proteins, thus suppressed the apoptosis of CRC cells (Figure 5C, D). The gene discussed is CASP3; the disease is colorectal carcinoma.