19. In addition, CLT also has a significant effect on renal fibrosis 44. However, the mechanism of CLT treatment for IgAN is still unclear. This study found that CLT effectively alleviated renal lesions and macrophage infiltration and improved renal function in IgAN mice after 3-weeks of intraperitoneal injection. In addition, after CLT intervention, the expression of iNOS, IL-6, and TNF- α was decreased, and the expression of CD206 and Arg-1 was increased in vivo and LPS-induced Raw 264.7 cells. Here, MRC1 is linked to renal fibrosis.