In prostate adenocarcinoma cells, celastrol modulated the protein expression of IκBα, IKKα (kappa B inhibitory kinase α subunit), p50, and NF-κB, promoted the degradation of the anti-apoptotic protein Mcl-1, and activated the pro-apoptotic protein Noxa. This evidence concerns the gene NFKB1 and prostate adenocarcinoma.