EGFR and lung carcinoma: Similarly, another study revealed that celastrol, when combined with EGFR tyrosine kinase inhibitors (EGFR-TKIs), effectively inhibits the growth and invasion of T790M mutant human lung cancer H1975 cells by suppressing the expression and phosphorylation of EGFR, STAT3, p-Akt, and p-ERK 129.