SIRT1 and colorectal carcinoma: Importantly, by using the specific SIRT1 activator SRT1720, the SIRT1 inhibitors NAA and EX527, several siRNAs against SIRT1, and overexpression of SIRT1 WT and constitutively active K610R and inactive H363Y mutants, we convincingly show that the depletion of nuclear β-catenin and the antiproliferative effects exerted by 1,25(OH)2D3 in CRC cells rely on SIRT1 induction and subsequent β-catenin deacetylation.