In line with these results, SIRT1 inhibition with EX527 abolished the antiproliferative effect of 1,25(OH)2D3 on CRC cells (Figure 3H), while similar antiproliferative effects were obtained by activation of SIRT1 with either 1,25(OH)2D3 or SRT1720 (Figure 3I). Here, SIRT1 is linked to colorectal carcinoma.