Although Liu et al.50 reported that SIRT1 is overexpressed in certain tumours, suggesting that SIRT1 acts as tumour promoter, Wang et al.51 reported that SIRT1-deficient embryos exhibit genomic instability and increased tumourigenesis, and Firestein et al.52 showed that SIRT1 suppressed tumour growth in a mouse CRC model driven by Wnt/β-catenin. The gene discussed is SIRT1; the disease is neoplasm.