Furthermore, we constructed a protein–protein interaction (PPI) network to explore the interactions among the 10 PRGs and compared their expression differences between tumor and normal groups, as well as between pyroptosis subtypes A and B. Among the identified PRGs, TNNC1 was specifically expressed in colon cancer samples and cells, promoting further exploration of its role in CC. This evidence concerns the gene GART and malignant colon neoplasm.