IFNG and cancer: Moreover, genetic modification had a notable impact on their secretory profile, leading to a substantial increase in various anti-tumor immune soluble factors such as IFN-γ, IL-2, MCP-1, and IL12p40 (Figure 4C).114 Several studies in the recent decade have shown that anticancer drug-conjugated nanoparticle-loaded MSCs, due to the increasing migration activity of MSCs and controlled and gradual drug- release in target tissue, can be introduced as a novel tool in cancer therapy.115-117